Those suffering with schizophrenia or other mental or psychotic disorders should not consume Ayahuasca.
If you have high blood pressure or a heart condition, or if you are receiving treatment for any health condition, it is advisable to consult your doctor before drinking Ayahuasca. It is also recommended you consult your physician if you are taking prescription medications (including antibiotics).
Medical consultation is essential if you are taking Prozac or another antidepressant that affects serotonin levels. SSRIs (serotonin selective re-uptake inhibitors) such as found in certain antidepressant drugs block the re-uptake of serotonin in the brain. MAOIs (monoamine oxidase inhibitors) such as found in Ayahuasca inhibit the breakdown of serotonin. The combination can lead to excessive levels of serotonin in the brain. Seek the advice of a medical professional but be aware that SSRI medications typically need to be reduced gradually and can take up to six weeks to clear the body.